A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension
Completed · Not applicable
Conditions studied: Hypertension, Plasma Renin Activity
In brief
The purpose of this study is to investigate the effect of plasma renin activity-guided therapy for determining hypertension treatment. Plasma renin is an enzyme in your blood that can be measured to determine your hypertension subtype. Once the subtype is known, doctors can prescribe specific medications to target your specific hypertension subtype. This study will investigate whether targeting the specific hypertension subtype helps to achieve blood pressure control sooner and with fewer medications compared to a standard fixed dose combination therapy.
Key facts
- Study ID
- NCT01658657
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 17
- Starts
- 2012-10-01
- Expected to finish
- 2014-07-01
- Last updated by the study team
- 2015-08-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Systolic BP average during at least one recent (within 1 month) clinic or emergency room visit ≥ 150 mmHg, or diastolic BP average during at least one recent (within 1 month) clinic or emergency room visit ≥ 95 mmHg
- Not currently taking BP-lowering medication
- Clinician recommends pharmacologic treatment
- Willing to make necessary study visits
- Able to be contacted by phone
- Has a primary care clinician
- At least 18 years old
You may not qualify if…
- Known secondary cause of hypertension
- Pregnancy
- Known diabetes, coronary artery disease or renal disease
- Known sulfonamide allergy or history of gout
- Participant's clinician recommends he/she not enroll
- Hyponatremia, hypokalemia, hypernatremia, or hyperglycemia at baseline visit
- Baseline visit systolic visit BP average < 140 mmHg and diastolic BP average < 90 mm Hg
- Resting heart rate < 55 beats per minute
Where it is running
- UNC Chapel Hill — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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