Short-term Clinical Effects of Intravitreal Aflibercept Injection 2.0mg as a Predictor of Long-term Results

Status unconfirmed · Phase 4

Conditions studied: Age Related Macular Degeneration

In brief

This is an open label study to evaluate 2.0 mg intravitreal aflibercept injection administered in subject who have active choroidal neovascularization due to Age Related Macular Degeneration (AMD).

Key facts

Study ID

NCT01657669

Run by

Retina Research Institute, LLC

People needed

22

Starts

2012-10-01

Expected to finish

2017-12-01

Last updated by the study team

2017-10-27

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to provide written informed consent and comply with study assessments for the full duration of the study.
• Age 50 years and above.
• Choroidal neovascularization secondary to AMD with central retinal thickness greater than or equal to 300um.
• Best corrected visual acuity in the study eye between 20/40 and 20/400 using an ETDRS chart -

You may not qualify if…

• Pregnancy (positive urine pregnancy test) or lactation.
• Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an IUD, or contraceptive hormone implant or patch.
• Participation in a study or an investigational drug or device within the past 30 days prior to enrolling in the study.
• Presence of significant subfoveal fibrosis or atrophy.
• Previously treated subjects:
• Prior treatment with anti-VEGF therapy in the study eye within 28 days of baseline More than six (6) prior treatments with anti-VEGF therapy in the study eye within 1 year.
• Prior treatment with PDT within the past 3 months or more than 2 prior PDT treatments.
• Prior treatment with intravitreal aflibercept injection Prior treatment with triamcinolone in the study eye within 6 months of baseline.
• Prior treatment with dexamethasone in the study eye within 30 days prior to baseline.
• Intraocular surgery (including cataract surgery)in the study eye within 2 months preceding baseline
• History of vitrectomy surgery, submacular surgery, or other surgical intervention for AMD in the study eye.
• Active intraocular inflammation (grade trace or above) in the study eye
• Current vitreous hemorrhage in the study eye
• History of rhegmatogenous retinal detachment or macular hole (Stage 3 or 4) in the study eye.
• Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye.
• Uncontrolled glaucoma in the study eye (defined as IOP greater than or equal to 30 mmHg despite treatment with anti-glaucoma medication)
• History of cerebral vascular accident, myocardial infarction, transient ischemic attacks within 3 months of study enrollment.
• History of allergy to fluorescein, ICG or iodine, not amenable to treatment
• History of retinal pigment epithelial tear or rip.

Where it is running

• The Retina Institute — St Louis, Missouri, United States
• The Retina Institute — St Louis, Missouri, United States
• Valley Retina Institute — McAllen, Texas, United States

Full record on ClinicalTrials.gov

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