Phase 2 Efficacy Trial of Z160 in Lumbosacral Radiculopathy

Completed · Phase 2 · Has a placebo group

Conditions studied: Lumbosacral Radiculopathy

In brief

This study will compare Z160 and placebo in patients with Lumbosacral Radiculopathy for safety and efficacy for a period of 6 weeks.

Key facts

Study ID

NCT01655849

Run by

Zalicus

People needed

141

Starts

2012-08-01

Expected to finish

2013-11-01

Last updated by the study team

2013-12-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The subject must have a diagnosis of pain due to LSR, with all of the following characteristics:
• The subject perceives pain in one or both lower limbs at sites that are consistent with the area innervated by the L4, L5, or S1 nerve roots, with or without other sensory symptoms in the affected areas (typically, the pain may be perceived in the buttock, thigh, calf, leg, foot, or toes).
• The history of the pain suggests that the cause of the LSR is due to injury of the lumbosacral nerve root(s) by degenerative disease of the vertebrae in the lumbosacral spine or associated soft tissues (including the intervertebral discs).
• The duration of pain since onset is ≥ 12 weeks.
• Based on clinical history, the intensity of pain has been stable during the 2-week period before screening.
• In the investigator's opinion, the subject's diagnosis of LSR is supported by all of the following at screening:
• Based on the StEP instrument:
• Neurological examination of lower limbs shows impaired muscle power, sensory function, or deep tendon reflexes in the territory of the affected nerve roots.
• Pain/sensory disturbance in dermatomal/myotomal distribution is precipitated or exacerbated by straight leg raising (the straight-leg-raising test should be performed as specified in StEP).
• The total StEP score is ≥ 4 (indicative of LSR as the cause of the pain)
• At screening, the subject has an average daily pain score for neuropathic pain due to LSR of ≥ 3 and ≤ 8 on the PI-NRS.
• If female, the subject must be postmenopausal (defined as no menstruation for at least 12 months), surgically sterilized for ≥3 months before the screening visit, or agree to use 2 reliable methods of contraception (oral, implantable, transdermal, or injectable contraceptives in conjunction with an intrauterine device or a barrier method) during the 6-week treatment period, during the 6 week posttreatment follow-up period, and for an additional 8 weeks after the last study visit (Week 12, Visit 9) to avoid pregnancy if of childbearing potential (defined as biologically capable of becoming pregnant). If male, the subject must agree to use condoms during the 6-week treatment period with the study drug, during the 6-week posttreatment follow up period, and for an additional 8 weeks after the last study visit (Week 12, Visit 9).

You may not qualify if…

• The subject has:
• Neuropathic pain due to causes other than that specified in the inclusion criteria (e.g., postherpetic neuralgia; painful diabetic neuropathy; mononeuritis multiplex; central poststroke pain; failed back surgery in relation to the presenting episode of radiculopathy; spinal abscess, infection, hematoma, or malignancy; phantom limb pain; peripheral neuropathy due to alcoholism, malignancy, human immunodeficiency virus [HIV], syphilis; drug abuse; vitamin B12 deficiency; hypothyroidism; liver disease; toxic exposure).
• Pain that is associated with a substantial somatic pain component (e.g., non-neuropathic/musculoskeletal pain in lower limbs or other parts of the body apart from the back) or more than one cause or potential cause for pain symptoms.
• Any painful concurrent rheumatic disease such as, but not limited to, fibromyalgia, rheumatoid arthritis, or significant osteoarthritis.
• Any question regarding the acceptability of the etiology of the neuropathic pain should be discussed with the Zalicus medical monitor.
• In the investigator's opinion, the subject is unable to reliably delineate or assess his or her own pain by anatomical location/distribution (e.g., the subject cannot reliably tell the difference between his or her back pain and lower limb pain and cannot rate the intensity of each separately).
• The subject has pain in the lower limbs solely upon walking and not at rest.
• The subject has undergone surgery for LSR within the last 6 months or has received treatment with epidural injections, nerve blocks, or acupuncture for LSR within 4 weeks before screening.
• The subject has:
• A history of seizure, excluding pediatric febrile seizures, or currently has seizures
• A history of or a current diagnosis of schizophrenia or bipolar disorder
• Had a stroke or TIA ≤ 6 months before the screening visit
• Has an episode of major depression or generalized anxiety disorder ≤ 6 months before the screening visit.
• The subject has a history of or currently has any of the following conditions that, in the investigator's opinion, may interfere with the study procedures or compromise the subject's safety:
• Cardiovascular disease
• Gastrointestinal disease
• Hepatic disease
• Respiratory disease
• Renal disease
• Any condition that is known to interfere with the absorption, distribution, metabolism, or excretion of drugs
• The subject has a history of or currently has:
• Any clinically significant vital sign, ECG, or laboratory abnormalities.
• QTcF >450 msec (males) or >470 msec (females)
• The subject had a malignancy.
• The subject has had a positive test for HIV antibody or a history of HIV.

Where it is running

• Investigative Site — Huntsville, Alabama, United States
• Investigative Site — Peoria, Arizona, United States
• Investigative Site — Anaheim, California, United States
• Investigative Site — Fresno, California, United States
• Investigative Site — Orange, California, United States
• Investigative Site — Sacramento, California, United States
• Investigative Site — Clearwater, Florida, United States
• Investigative Site — Clearwater, Florida, United States
• Investigative Site — Orlando, Florida, United States
• Investigative Site — Pinellas Park, Florida, United States
• Investigative Site — Plantation, Florida, United States
• Investigative Site — Royal Palm Beach, Florida, United States
• Investigative Site — Atlanta, Georgia, United States
• Investigative Site — Overland Park, Kansas, United States
• Investigative Site — Shreveport, Louisiana, United States
• Investigative Site — Boston, Massachusetts, United States
• Investigative Site — Hazelwood, Missouri, United States
• Investigative Site — Las Vegas, Nevada, United States
• Investigative Site — Medford, Oregon, United States
• Investigative Site — Duncansville, Pennsylvania, United States
• Investigative Site — Dallas, Texas, United States
• Investigative Site — Sandy City, Utah, United States
• Investigative Site — Bellevue, Washington, United States

Full record on ClinicalTrials.gov

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