Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery

Recruiting now · Not applicable

Conditions studied: Congenital Heart Disease, Heart Valve Disease

In brief

Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft. The investigators recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. The investigators further investigate that whether simvastatin can protect myocardium during noncoronary artery cardiac surgery with cardiopulmonary bypass and improve cardiac function with long term use postoperatively in two medical centers.

Key facts

Study ID

NCT01653223

Run by

Sun Yat-sen University

People needed

369

Starts

2013-01-01

Expected to finish

2026-12-01

Last updated by the study team

2023-04-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• More than 18-year-old,
• Congenital heart disease(not complex),
• Isolated heart valve disease,

You may not qualify if…

• Coronary artery disease
• Allergy for statins
• Poor liver function,Hepatitis
• Gestation women and Breast-feeding women

Where it is running

• The First Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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