Resistance Training and Testosterone After Spinal Cord Injury

Completed · Phase 2/Phase 3

Conditions studied: Spinal Cord Injury

In brief

The goal of this proposal is to investigate the efficacy of a complimentary approach of evoked resistance training and testosterone replacement therapy on the changes in body composition and metabolic profile after SCI. The proposed method could become a recommended and simple intervention especially for individuals with limited access and poor tolerance to exercise. The rationale is based on the evidence that individuals with SCI experience decline in anabolic hormones which may be responsible for the deterioration in body composition and metabolic profiles and leads to increase obesity, type 2 diabetes mellitus, dyslipidemia and subsequently cardiovascular disease. The designed study will provide explanation to the adaptations in the energy source of the muscle cells in response to training.

Key facts

Study ID

NCT01652040

Run by

VA Office of Research and Development

People needed

26

Starts

2012-07-02

Expected to finish

2017-12-30

Last updated by the study team

2018-05-03

Who can join

Age: 18 and older, up to 50. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male with Spinal Cord Injury
• Between 18-50 years old
• BMI < 30 Kg/m2
• Traumatic motor complete C5-L2 level of injury
• American Spinal Injury Classification (A and B; i.e. motor deficit below the level of injury)

You may not qualify if…

• Cardiovascular disease
• Uncontrolled type II DM and those on insulin
• Pressures sores stage 2 or greater
• Supra-physiological T level
• Hematocrit above 50%
• Urinary tract infection or symptoms

Where it is running

• Hunter Holmes McGuire VA Medical Center, Richmond, VA — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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