Predicting Cognitive Resilience Against Sleep Loss
Completed · Not applicable
Conditions studied: Sleep Deprivation
In brief
Resilience is the ability to cope effectively and adapt to a wide range of stressful environmental challenges. Sleep loss has been shown to reduce activity in the brain regions responsible for resilience. The ability to resist the effects of sleep loss appears to be a stable, trait-like quality. This study will attempt to predict individuals' trait-resistance to sleep loss based on their neurobiology.
Key facts
- Study ID
- NCT01651429
- Run by
- Mclean Hospital
- People needed
- 48
- Starts
- 2013-04-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2014-06-16
Who can join
Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 20-45 years
- Right handedness as assessed by the Edinburgh Handedness Inventory
- For women: regular menstrual cycles (duration between 25 and 35 days with no more than 3 day variation between cycle)
You may not qualify if…
- History of head injury with loss of consciousness or post-traumatic amnesia, or major neurological illness
- Medical or neurologic condition that would confound interpretation of results, including alcohol or drug abuse/dependence in the past 6 months, neurological disorders including any history of seizures
- History of cardiac problems
- History of major depressive disorder or anxiety disorder
- Lifetime history of psychotic disorder, including bipolar disorder, schizophrenia, or obsessive compulsive disorder
- Other DSM-IV diagnosis that could affect interpretation of results
- Mixed or left handedness
- Abnormal visual acuity that cannot be corrected by contact lenses
- Daily caffeine use exceeding 400 mg per day
- History of smoking or tobacco use in the past year
- Metal within the body, pregnancy, or other contraindication for MRI procedures
- Use of drugs or medications that could affect functional neuroimaging results (e.g., fluoxetine, beta-blockers)
- Psychotropic medication use within the past 6 weeks
Where it is running
- McLean Hospital — Belmont, Massachusetts, United States
Full record on ClinicalTrials.gov
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