In-situ Evaluation of Anti-caries Technology

Completed

Conditions studied: Caries

In brief

Three toothpastes will be compared, two toothpastes in each subject, to establish whether changes in the depth or area of an artificially created area of tooth decay is the same for each toothpaste.

Key facts

Study ID

NCT01650493

Run by

Solventum US LLC

People needed

29

Starts

2012-06-01

Expected to finish

2013-07-01

Last updated by the study team

2024-10-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• generally good physical health
• at least 18 years old
• needs a full crown on a mandibular first or second molar tooth
• tooth brushing frequency of twice daily or more
• agrees not to participate in other clinical study for duration of this study
• agrees to delay any elective dentistry, including dental prophylaxis, until study complete

You may not qualify if…

• any condition requiring antibiotic premedication before a dental procedure
• active treatment for cancer or seizure disorder
• diseases or conditions that could interfere with subject safely completing the study
• currently taking antibiotics or anti-cholinergic medications
• currently using extensive daily fluoride therapy
• gross, visible caries
• chronic use of chlorhexidine within 3 months of baseline
• use of systemic antibiotics within 7 days of baseline
• severe periodontal disease
• use of any fluoride rinses or gels one month prior to study initiation
• pregnancy, the intention to become pregnant
• presence of orthodontic bands or removable retainers

Where it is running

• Dows Institute for Dental Research — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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