CYP2B6 Polymorphisms in Methadone Disposition

Completed · Not applicable

Conditions studied: Healthy Volunteers

In brief

This research study will determine if genetic variation in CYP2B6 affects how the body metabolizes methadone.

Key facts

Study ID

NCT01648283

Run by

Washington University School of Medicine

People needed

78

Starts

2012-11-01

Expected to finish

2015-06-01

Last updated by the study team

2018-06-20

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Each subject must meet all of the following criteria:
• 18-50 yr old
• CYP2B6*1/*1, CYP2B6*1/*6 or CYP2B6*6/*6 genotype
• Good general health with no remarkable medical conditions
• BMI < 33
• Provided informed consent

You may not qualify if…

• Subjects will not be enrolled if any of the following criteria exist:
• Known history of liver or kidney disease
• Use of prescription or non prescription medications, herbals or foods known to be metabolized by or affect CYP2B6
• Females who are pregnant or nursing
• Known history of drug or alcohol addiction (prior or present addiction or treatment for addiction)
• Direct physical access to and routine handling of addicting drugs in the regular course of duty (this is a routine exclusion from studies of drugs with addiction potential)

Where it is running

• Washington University Schoool of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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