Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients

Completed · Phase 4

Conditions studied: Moderate to Advanced Chronic Periodontitis

In brief

The purpose of this study is to determine the effect of local application of minocycline microspheres on the periodontal inflammation and bone loss prevention in patients diagnosed with moderate-severe chronic periodontitis within a periodontal maintenance program.

Key facts

Study ID

NCT01647282

Run by

University of Nebraska

People needed

60

Starts

2012-10-01

Expected to finish

2015-12-01

Last updated by the study team

2023-09-25

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of moderate-severe chronic periodontitis
• attending regular periodontal maintenance visits at UNMC COD
• one quadrant with at least one > 5 mm interproximal pocket and 3 posterior teeth

You may not qualify if…

• systemic diseases which impact periodontal inflammation and bone turnover
• drugs which significantly impact periodontal inflammation and bone turnover
• surgical periodontal therapy within the last year
• pregnant or breast-feeding females

Where it is running

• University of Nebraska, College of Dentistry — Lincoln, Nebraska, United States
• Creighton University School of Dentistry — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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