A Trial of Neurocognitive and Supportive Therapy Interventions for Individuals With Parkinson's Disease

Completed · Not applicable

Conditions studied: Parkinson's Disease, Mild Cognitive Impairment

In brief

This randomized, controlled trial (RCT) evaluates the benefits of memory and problem solving training compared to supportive therapy in individuals with Parkinson's Disease with Mild Cognitive Impairment (MCI) and their support persons. Participants will be randomly assigned to receive memory and problem solving training or supportive therapy for 2-months. A 6-month follow up evaluation will establish if benefits remain over time. Impact of these therapies on thinking abilities, physical health, and patient and support person ratings of thinking skills, mood and quality of life will be evaluated. The memory and problem solving training is hypothesized to result in greater improvements and/or stability of function on neuropsychological tests of attention, working memory, learning, and memory skills compared to the supportive therapy condition. Both conditions are hypothesized to result in improved mood and quality of life ratings. Results from this study will determine whether memory and problem solving therapies and supportive therapy are easily used by and beneficial for individuals with Parkinson's Disease and Mild Cognitive Impairment. If positive benefit is observed, information from this study will be used to further optimize these therapies for larger trials designed to evaluate the value of the therapies for individuals with Parkinson's Disease and their support persons.

Key facts

Study ID

NCT01646333

Run by

Virginia Commonwealth University

People needed

32

Starts

2012-07-01

Expected to finish

2015-12-01

Last updated by the study team

2016-01-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of Parkinson's Disease
• Clinical diagnosis of Mild Cognitive Impairment

You may not qualify if…

• Clinical diagnosis of Dementia
• Clinical diagnosis of other Parkinson's Disease-associated comorbid conditions (e.g., severe anxiety, depression, excessive daytime sleepiness, or psychosis) that significantly influence cognitive testing

Where it is running

• VCU Parkinson's and Movement Disorders Center — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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