Exhaled Nitric Oxide and Airway Caliber in Children With Asthma

Completed

Conditions studied: Asthma in Children

In brief

The purpose of this study is to assess if in steroid naïve asthmatic children with elevated baseline exhaled nitric oxide, treatment with inhaled steroid and normalization of exhaled nitric oxide level results in restoration of the bronchodilator response to deep inhalation.

Key facts

Study ID

NCT01645397

Run by

Atlantic Health System

People needed

20

Starts

2011-06-01

Expected to finish

2013-08-01

Last updated by the study team

2014-01-16

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: > 6 years at age of screening.
• Physician diagnosed asthma
• Elevated exhaled NO at initial evaluation (>25ppb)
• Be able to reproducibly perform DI maneuvers and all other pulmonary function testing
• Be clinically stable for at least 2 weeks prior to screening with no evidence of acute upper or lower respiratory infection or current pulmonary exacerbation.
• Has not been on inhaled or oral steroid for at least 4 weeks prior to enrollment in the study.
• Parent/child willingness to enroll in the study and provide written informed consent.
• Be able to present for the required study visits.

You may not qualify if…

• Chest wall or spinal column deformity; known cardiac, neuromuscular, or other chronic diseases
• Use of beta agonist, theophylline, leukotriene receptor antagonists, or caffeine-containing soft drinks 12 hr prior to the study.
• Use of inhaled steroid in the past 4 weeks.
• Respiratory infection or asthma exacerbation in the previous 2 weeks

Where it is running

• Goryeb Children's Hospital, Atlantic Health — Morristown, New Jersey, United States

Full record on ClinicalTrials.gov

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