Non-invasive Diagnosis of Portal Hypertension With Acoustic Radiation Force Impulse (ARFI)

Completed · Not applicable

Conditions studied: Portal Hypertension, Chronic Liver Disease

In brief

The aim of this diagnostic study is to evaluate the efficacy of ARFI imaging (a specific type of ultrasound) in assessing the pressure of the portal vein (the major vein passing through the liver) and the amount of liver fibrosis in patients with chronic liver disease.

Key facts

Study ID

NCT01644656

Run by

VA Connecticut Healthcare System

People needed

500

Starts

2012-07-01

Expected to finish

2018-09-01

Last updated by the study team

2018-09-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 18-85 years
• compensated chronic liver disease with suspected or confirmed liver cirrhosis sent for transjugular liver biopsy as part of their routine care
• signed informed consent

You may not qualify if…

• known contraindications to the performance of an HVPG measurement or a trans-jugular biopsy
• portal thrombosis
• previous surgical or transjugular portosystemic shunt
• previous total or partial splenectomy
• presence of comorbid conditions conferring a life expectancy of less than 1 year

Where it is running

• Yale-New Haven Hospital — New Haven, Connecticut, United States
• VA Connecticut Healthcare System — West Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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