Evaluation of the Association Between Genetic Load and Response to Anti-VEGF Therapy in AMD Patients

Completed

Conditions studied: Age Related Macular Degeneration

In brief

Patients with AMD who are being or have been treated with eye injections of drugs known as anti-VEGF agents with either good or poor response will have DNA collected with check swabs for analysis.

Key facts

Study ID

NCT01644513

Run by

Sequenom, Inc.

People needed

196

Starts

2012-07-01

Expected to finish

2012-12-01

Last updated by the study team

2013-02-12

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject is male or female 55 years of age and older
• Subject is self-reported as non-Hispanic Caucasian
• Subject provides a signed and dated informed consent
• Subject agrees to provide two buccal swabs in accordance with this protocol
• Diagnosis of CNV secondary to AMD in at least one eye
• Subject satisfies one of the following:
• Has received at least one injection of anti-VEGF therapy (bevacizumab or ranibizumab) with no evidence of residual subretinal or intra-retinal fluid present on SDOCT one month (+/- 1 week) following most recent injection; or
• Has received three or more injections in last six months with residual subretinal or intra-retinal fluid present on SDOCT one month (+/- 1 week) following most recent injection, has not shown complete resolution of fluid following any injection in last 6 months, and shows leakage on FA or ICG imaging at some time during last 12 months.

You may not qualify if…

• Previous sample donation under this protocol
• Presence of retinal disease involving the photoreceptors and/or outer retinal layers other than AMD loss such as high myopia, retinal dystrophies, central serous retinopathy, vein occlusion, diabetic retinopathy and uveitis or similar outer retinal diseases which have been present prior to the age of 50.
• Opacities of the ocular media, limitations of pupillary dilation or other problems sufficient to preclude adequate imaging of the posterior segment.

Where it is running

• Ophthalmic Consultants Boston — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.