Heritability of Fatty Liver as Measured by MRI: a Cross Sectional Study of Twins and Family Members
Status unconfirmed
Conditions studied: Liver Disease
In brief
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States. The cause of NAFLD is poorly defined but is thought to involve complex interactions of genetic and environmental factors. NAFLD is often associated with the traits of the metabolic syndrome including diabetes, high cholesterol or elevated blood pressure. Currently, there are no accurate noninvasive means of evaluating NAFLD and its more serious form which includes inflammation that may lead to severe scarring in the liver. The goal of this study is to evaluate shared genetic factors that underlie NAFLD and features of the metabolic syndrome as determined by blood work and radiographic studies in a cohort of twins and first degree relatives.
Key facts
- Study ID
- NCT01643512
- Run by
- University of California, San Diego
- People needed
- 500
- Starts
- 2011-08-01
- Expected to finish
- 2021-08-01
- Last updated by the study team
- 2021-05-06
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects must be at least 18 years of age
- The subject is willing and able to complete all procedures and observations specified in the protocol
- The subject has been fully informed and has personally signed and dated the written Informed Consent/Assent and Health Insurance Portability and Accountability Act (HIPAA) provisions.
You may not qualify if…
- The subject is a female who is pregnant or nursing.
- Contraindications to MRI:
- The subject has any contraindication to MR imaging, such as patients with pacemakers, metallic cardiac valves, magnetic material such as surgical clips, implanted electronic infusion pumps or other conditions that would preclude proximity to a strong magnetic field.
- The subject has a history of extreme claustrophobia.
- The subject cannot fit inside the MR scanner cavity
Where it is running
- University of California, San Diego — San Diego, California, United States (enrolling)
Full record on ClinicalTrials.gov
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