Chronic Moderate Sleep Restriction in Older Adults

Completed · Phase 1

Conditions studied: Sleep Disturbance, Aging

In brief

Higher rates of mortality have been found both in short sleepers (\< 6 hr/night) and long sleepers (\> 8 hr/night), but there has been little experimental investigation of the effects of chronic, moderate sleep loss in long or average sleepers. Some scientists argue that older adults might be particularly vulnerable to negative effects of sleep loss, whereas other scientists argue that many older adults spend too much time in bed, and that moderate reduction of time-in-bed could help increase the quality of their sleep, and could even promote health and longevity, particularly in long sleepers. At 4 sites across the US, we will conduct a large (200 people), randomized, controlled, 5- year study to examine whether a 1-hour reduction of time spent in bed for 12 weeks has negative or positive effects on multiple health-related outcomes, including inflammation, sleepiness, body weight, mood, glucose regulation, quality of life, incidence of illness, and incidence of automobile accidents in older long sleepers as compared to older average sleepers.

Key facts

Study ID

NCT01642719

Run by

University of California, Los Angeles

People needed

200

Starts

2012-07-01

Expected to finish

2018-12-01

Last updated by the study team

2019-07-18

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 60-80 years of age
• Sleeping an average of 8-9 hr per night for long sleeper (or)
• Sleep an average of 6.0-7.25 hr per night for short sleepers
• Able to designate a study partner that can speak on their behalf throughout the course of the study.

You may not qualify if…

• Reported average sleep duration of < 8.0 hr or > 9.0 hr for longer sleepers
• Reported average sleep duration of < 6 hr or > 7.25 hr for the average sleepers
• Spending > 30 min time in bed in the morning and/or night outside of the major sleep period (e.g., watching tv)
• Expected change in usual sleep duration in the near future (e.g., change in work schedule)
• Reported average napping of > 2 naps/day or total nap duration of > 90 min/day;
• Recent shift-work (previous 2 months) or travel across multiple time zones (previous 4 weeks), or plans for performing shift-work or transmeridian travel during the study time period;
• Severe sleep apnea (apnea-hyponea index of greater or equal 15);
• Obesity (body mass index ≥35);
• High daytime sleepiness (Epworth Sleepiness Scale ≥ 10);
• Depression (Quick Inventory of Depressive Sympotomology > or equal to 16);
• Use of hypnotics or other drugs prescribed to promote sleep;
• Alcohol dependence or drug use;
• Any medical, neurologic, or psychiatric illness causing long sleep;
• Factors associated with significant changes in inflammation, including several medical disorders (e.g., rheumatoid arthritis), medications (e.g., steroids) and current smoking;
• Any health or mental condition that would contraindicate participation in the rigors of the study

Where it is running

• University of Arizona — Tucson, Arizona, United States
• UCLA Cousins Center for Psychoneuroimmunology — Los Angeles, California, United States
• SUNY Downstate Medical Center — Brooklyn, New York, United States
• University of South Carolina — Columbia, South Carolina, United States

Full record on ClinicalTrials.gov

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