Impact of Buspirone Maintenance on the Reinforcing Effects of Cocaine
Completed · Not applicable · Has a placebo group
Conditions studied: Cocaine Use Disorders
In brief
Cocaine use disorders are an unrelenting public health concern. Intensive research efforts have yielded behavioral interventions that reduce cocaine use, however, these interventions are not universally effective and treatment effects diminish over time. Development of a pharmacotherapy that enhances the efficacy of these interventions is a priority for the National Institute on Drug Abuse. This study proposes to determine the impact of buspirone maintenance on self-administration of cocaine and alternative reinforcers. These preliminary data will be used to support further research developing buspirone as a pharmacotherapy for cocaine use disorders. We hypothesize that buspirone will attenuate the reinforcing effects of cocaine and increase the reinforcing effects of alternative reinforcers.
Key facts
- Study ID
- NCT01639157
- Run by
- William Stoops
- People needed
- 9
- Starts
- 2012-09-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2016-02-19
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Recent cocaine use
You may not qualify if…
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation
- Females not currently using effective birth control
- Contraindications to cocaine or buspirone
Where it is running
- University of Kentucky Medical Center — Lexington, Kentucky, United States
Full record on ClinicalTrials.gov
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