The Cyclical Lower-extremity Exercise for Parkinson's Trial

Completed · Not applicable

Conditions studied: Parkinson's Disease

In brief

The purpose of this study is to gain a better understanding of how exercise training affects motor/hand function and brain function in those diagnosed with Parkinson's disease. The investigators want to study if exercise will improve hand function and improve the level of brain activity.

Key facts

Study ID: NCT01636297
Run by: The Cleveland Clinic
People needed: 100
Starts: 2013-06-01
Expected to finish: 2017-12-01
Last updated by the study team: 2018-09-26

Who can join

Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Able to provide informed consent.
Clinical diagnosis of idiopathic PD. The diagnosis of PD will be based on the presence of at least two of the cardinal signs of this disorder (akine¬sia/bradykinesia, rest tremor, rigidity, gait and postural instability) with at least one of the signs being rest tremor or akinesia/bradykinesia.
Hoehn and Yahr stage II-III when off PD medication.
UPDRS motor score between 6-45 out of a maximum of 108 when off PD medication.
Stable anti-parkinsonian medication for one month prior to study enrollment or consistent in desire to stay off anti-parkinson medication.
Age between 30 and 75 years.

You may not qualify if…

Clinically significant medical disease that would increase the risk of exercise-related complications (e.g. cardiac or pulmonary disease, diabetes mellitus, hypertension, stroke).
Dementia as evidenced by a score less than 116 on the Mattis Dementia Rating Scale.
Other medical or musculoskeletal contraindications to exercise.
Undergone any surgical procedure for treatment of PD, DBS, pallidotomy or thalamotomy

Where it is running

Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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