Combination Therapy to Treat Sleep Apnea
Completed · Not applicable · Has a placebo group
Conditions studied: Sleep Apnea, Obstructive
In brief
In Obstructive sleep apnea (OSA), the upper airway closes over and over again during sleep. This leads to disrupted sleep (waking up during the night), daytime sleepiness, and an increased risk for developing high blood pressure. Currently, the best treatment for obstructive sleep apnea is sleeping with a mask that continuously blows air into the nose (i.e. Continuous positive airway pressure \[CPAP\] treatment). While CPAP treatment stops the upper airway from closing in most people, many people have difficulty sleeping with the mask in place and therefore do not use the CPAP treatment. This research study is being conducted to learn whether using a combination of therapies (i.e. a sedative and oxygen therapy) will improve OSA severity by altering some of the traits that are responsible for the disorder.
Key facts
- Study ID
- NCT01633827
- Run by
- Brigham and Women's Hospital
- People needed
- 22
- Starts
- 2012-08-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2017-03-03
Who can join
Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ages 18 - 79 years
- Documented OSA (AHI > 10 events/hr Non rapid eye movement sleep supine)
- If treated then, current CPAP use (>4 hrs CPAP/night for > 2 months)
You may not qualify if…
- Any uncontrolled medical condition
- Any other sleep disorder (Periodic leg movement syndrome, restless legs syndrome, insomnia, etc.)
- Use of medications known to affect sleep/arousal, breathing, or muscle physiology
- Allergy to lidocaine or Afrin
- Claustrophobia
- Alcohol consumption within 24 hours of PSG
Where it is running
- Brigham and Women's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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