Heart Imaging in Children With Muscular Dystrophy

Stopped early

Conditions studied: Muscular Dystrophy

In brief

Background: \- Muscular dystrophy can affect the muscles used for heart function and breathing. Treatment usually involves drugs that help improve heart function. However, better types of heart imaging studies are needed to improve treatment of heart problems related to muscular dystrophy. Better heart imaging methods are especially needed for children with muscular dystrophy. Researchers want to test different heart imaging methods in children with muscular dystrophy. They will look at cardiac magnetic resonance imaging (MRI) and standard heart function tests. Objectives: \- To develop and test new methods for imaging the heart in children with muscular dystrophy. Eligibility: \- Children and adolescents between 8 and 17 years of age who have muscular dystrophy. Design: * Participants will be screened with a physical exam and medical history. * Participants will provide a blood sample at the start of the study. They will also have heart function tests before having the imaging study. * Participants will have a cardiac MRI scan that will last up to 60 minutes. Some tests will require a MRI contrast agent (a drug that helps the image appear more clearly on the scan).

Key facts

Study ID

NCT01633242

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

2

Starts

2012-02-24

Expected to finish

2016-10-11

Last updated by the study team

2019-09-13

Who can join

Age: 8 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Day-time users of continuous positive airway pressure (CPAP)
• Sip ventilator users
• Invasive ventilator dependent
• Pregnant minors (when uncertain, participants will undergo urine testing) or lactating minors
• Decompensated congestive heart failure (unable to lie flat during CMR)
• Impaired renal excretory function (calculated Glomerular Filtration Rate less than 30mL/min)
• Contra-indications to Magnetic Resonance Imaging:
• Cardiac pacemaker or implantable defibrillator
• Cerebral aneurysm clip
• Neural stimulator
• Metallic ocular foreign body
• Harrington-rod
• Any implanted device (i.e. insulin pump, drug infusion device)
• Claustrophobia
• Metal shrapnel or bullet
• Investigator assessment of inability to comply with protocol
• Unable/unwilling to lie still throughout the research procedure or who require sedation
• Persons with cognitive impairment

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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