Evaluating Intervention Responsiveness in People With Multiple Sclerosis

Completed · Not applicable

Conditions studied: Multiple Sclerosis

In brief

The purpose is to see how multiple sclerosis (MS) is associated with strength and sensation using MRI, in persons with MS. The investigators will also see whether exercise can improve these symptoms for persons with MS.

Key facts

Study ID

NCT01632293

Run by

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

People needed

60

Starts

2012-04-01

Expected to finish

2015-09-01

Last updated by the study team

2016-02-23

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Confirmed diagnosis of MS
• If on immunomodulatory therapy, subjects have to have been on that therapy for at least 6 months prior to the start of the study.
• Medically stable
• Able to follow complex directions as determined by a score of less than or equal to 1 on a subset of questions taken from the NIH Stroke scale
• Normal passive range of motion at the hips, knees, and ankles with minimum to no pain

You may not qualify if…

• Evidence of other neurological deficit that could interfere, such as previous stroke or muscle disease
• Congestive heart failure
• MS exacerbation within 8 weeks of study start
• MS exacerbation affecting CST or DC-ML tracts
• peripheral artery disease with claudication
• cancer
• pulmonary or renal failure
• unstable angina
• uncontrolled hypertension (greater than 190/110 mmHg)
• orthopedic or pain conditions
• history of kidney disease, due to potential of gadolinium reactions leading to nephrogenic systemic fibrosis (NSF)
• because pregnancy may change the MRI signals that we are studying, we have chosen not to enroll pregnant women in this study
• Healthy controls have the same age and exclusion criteria as people with multiple sclerosis except that they must have normal neurological function

Where it is running

• Motion Analysis Lab — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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