A Comparison of microRNA Samples in Patients With Nasal Polyps and Aspirin Exacerbated Respiratory Disease and Those With Nasal Polyps Only

Completed

Conditions studied: Aspirin-exacerbated Respiratory Disease, Nasal Polyp

In brief

We hypothesize that the miRNA expression in subjects with nasal polyps and Aspirin-exacerbated respiratory disease (AERD) differs from the miRNA expressed in subjects with nasal polyps but without Aspirin-exacerbated respiratory disease (AERD).

Key facts

Study ID

NCT01631773

Run by

University of South Florida

People needed

26

Starts

2011-08-01

Expected to finish

2012-06-01

Last updated by the study team

2014-10-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages eligible for study: 18 to 70 years
• Genders eligible for study: male and female
• Signed and dated written informed consent is obtained prior to study
• Subjects have a physician diagnosis of nasal polyps without AERD or physician diagnosis of nasal polyps with AERD. The diagnosis of aspirin sensitive asthma must be present for a minimum of three months. If the medical history is indeterminate either an aspirin challenge will be required to confirm or rule out the diagnosis. An aspirin challenge is a protocol that can safely be performed as an out patient procedure with close supervision.

You may not qualify if…

• Pregnant and/or lactating females.
• Current tobacco use.
• Severe psychiatric illness.
• Current illicit substance use or dependence and/or abuse of alcohol.
• Primary or secondary immunodeficiency.
• Any clinically significant uncontrolled medical condition that would put the patient at risk.

Where it is running

• USF Division of Allergy and Clinical Immunology Clinical Research Unit — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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