Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe

Status unconfirmed · Phase 4

Conditions studied: Clostridium Difficile Colitis

In brief

Once the lab test is positive for c. diff, the investigators will order the patient to have PEG 3350 solution, one 8oz glass every ten minutes until 6 liters are gone, but if still not clear 2 more liters may be ordered. At enrollment, the treatment arm will have an order for 500 cc Normal saline to be given I.V. The patient will continue with antibiotic treatment as well. The investigators will plan to check c. diff tests daily to see when they become negative. The investigators will perform chart audit/review to track mortality, the length of stay, ICU days, surgical intervention, and APACHE scores (assessment of disease severity). Chart audit will be used to collect data on their diet and how they feel using a visual analog scale (collected by nursing staff daily as a standard procedure; see attached pain scale). Using chart audit, the investigators will record whether the patient is immunocompromised or not.

Key facts

Study ID

NCT01630096

Run by

Ascension Health

People needed

200

Starts

2012-06-01

Last updated by the study team

2012-08-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years old or older male or female testing positive for c. diff

You may not qualify if…

• Pregnancy Less than 18 yrs of age Those sick enough to require surgery at diagnosis Severe ileus or small bowel obstruction

Where it is running

• Genesys Regional Medical Center — Grand Blanc, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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