Resistance Exercise in Barth Syndrome
Completed · Not applicable
Conditions studied: Barth Syndrome
In brief
Barth syndrome (BTHS) is a disorder that is characterized by heart failure, exercise intolerance and skeletal muscle weakness. Preliminary evidence demonstrates that endurance exercise training does not significantly improve exercise tolerance in BTHS. Because endurance exercise training targets a metabolic pathway that is adversely affected by BTHS, the investigators hypothesized that resistance training may improve exercise tolerance in BTHS because this type of training targets a different metabolic pathway than does endurance exercise. Therefore, the overall objective of the pilot/feasibility/proof-of-concept proposal is to collect preliminary data on the following hypothesis: Supervised resistance exercise training (3x/wk, 45min, 12 wks) will improve exercise tolerance, heart function, muscle strength and quality of life, and will be found safe in adolescents and young adults with BTHS.
Key facts
- Study ID
- NCT01629459
- Run by
- Washington University School of Medicine
- People needed
- 12
- Starts
- 2012-06-01
- Expected to finish
- 2019-06-30
- Last updated by the study team
- 2020-05-13
Who can join
Age: 15 and older, up to 35. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Age 15-35 years
- Sedentary (exercises less than 2x/wk)
- Motivated to exercise (BTHS only)
- Stable on medications for ≥ 3 months (BTHS only)
- Lives in North America
- Lives in the St. Louis area (Controls only)
You may not qualify if…
- Unstable heart disease
- Cardiac transplantation
Where it is running
- Washington University — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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