Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence

Completed · Not applicable

Conditions studied: Cigarette Smoking

In brief

The purpose of the study is to learn more about tobacco dependence and nicotine metabolism in African-Americans and whites, by studying to see if how fast a person metabolizes nicotine (how the body breaks down nicotine into inactive compounds) affects how dependent they are on smoking cigarettes. The investigators believe that people with a faster rate of metabolism may have more severe nicotine withdrawal symptoms and also may have a harder time trying to quit smoking.

Key facts

Study ID

NCT01627392

Run by

University of California, San Francisco

People needed

305

Starts

2012-07-01

Expected to finish

2015-08-01

Last updated by the study team

2015-12-03

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• African-American or Caucasian
• Age 18-70 years
• Regular smoker of 5 or more cigarettes per day
• Saliva cotinine of 100 ng/ml or greater

You may not qualify if…

• Obese (BMI > 38) or underweight (BMI < 17)
• Major systemic or psychiatric condition
• Medications that are inducers of CYP2A6
• History of alcohol abuse
• Positive drug urine tox test
• Pregnancy or breast feeding

Where it is running

• San Francisco General Hospital — San Francisco, California, United States

Full record on ClinicalTrials.gov

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