Studying Mechanisms of Radiation Therapy Resistance in Samples From Younger Patients With Rhabdomyosarcoma

Completed

Conditions studied: Alveolar Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma, Previously Treated Childhood Rhabdomyosarcoma, Previously Untreated Childhood Rhabdomyosarcoma, Recurrent Childhood Rhabdomyosarcoma

In brief

This laboratory study is looking into mechanisms of radiation therapy resistance in samples from younger patients with rhabdomyosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer

Key facts

Study ID

NCT01626170

Run by

Children's Oncology Group

People needed

20

Starts

2012-06-01

Last updated by the study team

2016-07-14

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Tissues requested from the Children Oncology Group (COG) sarcoma banking protocol COG-D9902
• All subtypes of rhabdomyosarcoma specimens
• Matched primary-relapsed specimens (from same patient, separated by time):
• Frozen tissue if available
• Scrolls of formalin-fixed paraffin-embedded tissue (if frozen not available)
• 10 unstained formalin-fixed paraffin-embedded thin sections
• All other general (primary or relapsed) cases
• 10 unstained formalin-fixed paraffin-embedded thin sections

Where it is running

• Children's Oncology Group — Monrovia, California, United States

Full record on ClinicalTrials.gov

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