Trial of IMO-3100 in Patients With Moderate to Severe Plaque Psoriasis
Completed · Phase 2 · Has a placebo group
Conditions studied: Actively Extending Plaque Psoriasis, Moderate to Severe Plaque Psoriasis
In brief
The purpose of this study is to evaluate different dose levels of IMO-3100 compared to placebo administered for 4 weeks to patients with moderate to severe plaque psoriasis.
Key facts
- Study ID
- NCT01622348
- Run by
- Idera Pharmaceuticals, Inc.
- People needed
- 44
- Starts
- 2012-05-01
- Expected to finish
- 2012-12-01
- Last updated by the study team
- 2018-01-09
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Is age 18 to 70 years, inclusive;
- Completes the informed consent procedure (see Section 15.3), including signing and dating the informed consent form;
- Has moderate to severe plaque psoriasis meeting the criteria specified above;
- Female subjects must have a negative pregnancy test at screening and on Day 1 prior to start of treatment;
- Female subjects of childbearing potential (see Section 8.4.1) and male subjects who have partners of childbearing potential must agree to use effective birth control (contraception; see Section 8.4.1) from Screening through the treatment period and for four (4) weeks after the last injection of study drug.
You may not qualify if…
- Has known hypersensitivity to any oligodeoxynucleotide;
- Is nursing;
- Has body weight < 50 kg;
- Has BMI > 34.9 kg/m2;
- Regularly consumes > 3 drinks of alcoholic beverages (beer, wine, or distilled spirits) per day;
- Has a positive test for antibody to human immunodeficiency virus (HIV-1 or -2) or hepatitis C virus;
- Has a positive test for hepatitis B surface antigen (HBsAg);
- Has at screening safety laboratory tests meeting one or more of the following criteria:
- hemoglobin < 10.5 g/dL
- white blood cell count < 4,000 cells/mm3
- absolute neutrophil count (ANC) < 1500/mm3
- platelet count < 100,000/mm3
- alanine transaminase (ALT; SGPT) > 1.5x ULN
- aspartate transaminase (AST; SGOT) > 1.5x ULN
- serum total bilirubin > 1.4x ULN
- serum creatinine > 1.3x ULN;
- Has a history of allogeneic organ transplant (including bone marrow or stem cells);
- Has, within the past 10 years, had evidence of or required treatment for cancer (except treated basal or squamous cell carcinoma of the skin or cured cervical carcinoma-in-situ);
- Has had within the past three months or is expected to have during the study period any of the following treatments:
- surgery requiring general anesthesia
- hematopoietic stimulating agents (e.g., erythropoietin, G-CSF, GM-CSF)
- another investigational drug;
- Has other significant medical disease (chronic or active within the past 6 months), including, but not limited to: cardiac disease (e.g., unstable angina, myocardial infarction, congestive heart failure, ventricular arrhythmia); uncontrolled seizure disorder; liver disease; chronic infection (e.g., tuberculosis); uncontrolled diabetes;
- Has any other condition that would, in the opinion of the Investigator, potentially compromise the safety or compliance of the patient or may preclude the patient's successful completion of the clinical trial.
Where it is running
- Florida Center for Dermatology, P.A — Jacksonville, Florida, United States
- Atlanta Dermatology, Vein & Research Center, PC — Alpharetta, Georgia, United States
- Dermatologic Surgery Specialists, Inc. — Macon, Georgia, United States
- Indiana Clinical Trials Center, PC — Plainfield, Indiana, United States
- DermResearch PLLC — Louisville, Kentucky, United States
- Tufts Medical Center — Boston, Massachusetts, United States
- Mass General Hospital Clinical Unit for Research Trials in Skin — Boston, Massachusetts, United States
- Derm Research Center of New York — Stony Brook, New York, United States
- Oregon Dermatology and Research Center — Portland, Oregon, United States
- Clinical Partners, Inc — Johnston, Rhode Island, United States
- J & S Studies — College Station, Texas, United States
- Center for Clinical Studies — Webster, Texas, United States
- University of Utah, Dermatology — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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