Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection With Mycobacterium Tuberculosis and in Predicting Progression to Tuberculosis

Completed

Conditions studied: Latent Tuberculosis Infection, Tuberculosis

In brief

This is a prospective cohort study of persons tested for latent tuberculosis infection at either high risk for exposure to Mycobacterium tuberculosis or high risk for progression to tuberculosis disease. The study will assess the relative performance and cost of three diagnostic tests for latent tuberculosis infection (tuberculin skin test, QuantiFERON-TB Gold In-Tube, and T-SPOT.TB) and will examine the rates of positive results among the cohort. This study will also determine the risk and rate of progression to active TB disease, overall and by the results of the three tests.

Key facts

Study ID: NCT01622140
Run by: Centers for Disease Control and Prevention
People needed: 21334
Starts: 2012-10-01
Expected to finish: 2020-12-31
Last updated by the study team: 2021-01-28

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

Where it is running

Maricopa County Department of Public Health — Phoenix, Arizona, United States
California Department of Public Health — Richmond, California, United States
Denver Health and Hospitals Authority — Denver, Colorado, United States
University of Florida Board of Trustees — Gainesville, Florida, United States
Emory University — Atlanta, Georgia, United States
Hawaii Department of Health — Honolulu, Hawaii, United States
Maryland Department of Public Health — Baltimore, Maryland, United States
Duke University — Durham, North Carolina, United States
University of North Texas Health Science Center — Fort Worth, Texas, United States
Public Health Seattle-King County — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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