MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain

Stopped early · Not applicable

Conditions studied: Chronic Low Back Pain, Diabetic Peripheral Neuropathy, Knee Osteoarthritis

In brief

This study is designed to assess: Hypothesis #1: That there is a significant central pain component in a distinct subset of patients diagnosed with knee osteoarthritis(KOA), Chronic low back pain(CLBP), painful diabetic neuropathy(PDN.) Hypothesis # 2: To establish a reliable strategy for differentiation of central pain predominant from peripheral pain predominant knee osteoarthritis(KOA), chronic low back pain(CLBP)and peripheral diabetic neuropathy(PDN) patients using clinical features, experimental pain testing and magnetic resonance(MR) Spectroscopy.

Key facts

Study ID

NCT01620775

Run by

University of Michigan

People needed

87

Starts

2012-09-01

Expected to finish

2017-06-07

Last updated by the study team

2018-06-04

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be Right Handed.
• (Chronic Pain with knee osteoarthritis)
• Diagnosed with: unilateral, symptomatic knee osteoarthritis based on American College of Rheumatology (ACR) criteria.
• Have had a knee x-ray within the last 6 months.
• Must have average pain intensity of 4 or greater on a 0 (no pain) to 10 (worst pain imaginable) scale.
• (Chronic Low Back Pain)
• Have primary complaint of constant or intermittent back pain of at least 6 months duration.
• Have a Roland Morris Disability Questionnaire score of >7.
• (Diabetes Mellitus with Painful Peripheral Neuropathy)
• Have a diagnosis of diabetes mellitus for at least 6 months.
• Have a diagnosis of diabetic peripheral neuropathy.
• Have had Electromyography(EMG) testing within the last 6 months.
• Have a >40 mm score on the short-form McGill Pain questionnaire.
• (Healthy controls)
• Must be pain free
• No history of neurological or psychiatric illness.
• No diagnosis of Diabetes Mellitus.
• No evidence of neuropathy on clinical assessment.

You may not qualify if…

• Being pregnant.
• Have metal in the body or other contraindications to Magnetic Resonance Imaging (MRI).
• Have a chronic pain condition unrelated to knee osteoarthritis, chronic low back pain or diabetes.
• Have currently or a history of brain infection, stroke or tumor.
• Have a risk factor for other non-diabetic neuropathies

Where it is running

• VA Hospital — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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