Adult-to-Adult Living Donor Transplant Cohort Study

Completed

Conditions studied: Liver Diseases, Hepatocellular Cancer, End Stage Liver Disease, Hepatitis C, Liver Cirrhosis

In brief

The study is being conducted for the following reasons: 1. To determine the prevalence, course, and predictors of poor Health Related Quality of Life (HRQOL) outcomes associated with living donor donation. 2. To collect data and biosamples prior to, during, and after a living donor liver transplant (LDLT) among all donors and recipients for use by other adult-to-adult living donor liver transplant studies and future studies. 3. To study the effects of pressure and flow on the outcomes of LDLT. 4. To characterize the differences between living donor liver transplant and deceased donor liver transplant in terms of recipient post-transplant outcomes including patient and graft survival, surgical morbidity, and resource utilization. 5. To compare the long-term histological outcomes in recipients of LDLT and deceased donor liver transplant (DDLT) with recurrent hepatitis C virus (HCV) infection. 6. To understand the history of pain management and to measure quality of care in pain control in living donors following partial hepatectomy.

Key facts

Study ID

NCT01619475

Run by

Arbor Research Collaborative for Health

People needed

1871

Starts

2011-02-01

Expected to finish

2014-08-01

Last updated by the study team

2019-02-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recipients
• Age 18 or older at the time of consent
• Has had a living donor identified and accepted and LDLT is planned
• Informed consent obtained
• Is listed for single organ (liver) transplantation
• Donors
• Age 18 or older at the time of consent
• Has undergone donor evaluation process and was accepted and donation surgery is planned
• Informed consent obtained

You may not qualify if…

• None

Where it is running

• University of California — San Francisco, California, United States
• University of Colorado Health Sciences — Aurora, Colorado, United States
• Northwestern University, Division of Transplantation — Chicago, Illinois, United States
• Lahey Clinic — Burlington, Massachusetts, United States
• Columbia University — New York, New York, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• Virginia Commonwealth University-Medical College of Virginia — Richmond, Virginia, United States
• University of Toronto — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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