Asymptomatic Colonization With S. Aureus After Therapy With Linezolid or Clindamycin for Acute Skin Infections

Stopped early · Not applicable

Conditions studied: Skin Diseases, Bacterial, Abscess

In brief

In this pilot study, the objective is to determine the prevalence of asymptomatic carriage of S. aureus in patients with ABSSSIs and minor cutaneous abscesses after therapy with either linezolid or clindamycin at 40 days after the completion of therapy. Secondarily, the investigators will assess the efficacy of linezolid vs. clindamycin in the empiric therapy of ABSSSIs and minor cutaneous abscesses, as well as the genotypic spectrum of S. aureus isolates causing ABSSSIs or minor cutaneous abscesses and colonization in the target patient population before and after therapy. Given the results of a recent study on linezolid and vancomycin and the investigator's own experience, it is hypothesized that persistent MRSA carriage will be less common after therapy with linezolid for ABSSSIs and minor cutaneous abscesses than it is with oral clindamycin.

Key facts

Study ID

NCT01619410

Run by

University of Chicago

People needed

25

Starts

2012-01-01

Expected to finish

2016-12-01

Last updated by the study team

2019-11-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• having an ABSSSI or a minor cutaneous abscess treated in the ED
• age 18 years or older
• any one or more of the following co-morbidities:
• diagnosis of diabetes mellitus
• obesity with a BMI >35
• chronic kidney disease
• coronary artery disease
• peripheral vascular disease

You may not qualify if…

• known history of or current thrombocytopenia
• Currently taking anti-depression medication
• Current or recent hospitalization
• Known current alcohol or drug abuse
• Known or suspected hypersensitivity to any ingredient of the study drugs
• Irregular heart rate and blood pressure measurements
• Fevers or low body temperature
• Known psychiatric condition
• Superficial skin infection
• Skin infection caused from an animal bite
• Recent treatment with antibacterials
• Pregnancy
• Other protocol related inclusion/exclusion criteria may apply.

Where it is running

• Grady Memorial Hospital — Atlanta, Georgia, United States
• University of Chicago Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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