Association of Endothelial Function and Clinical Outcomes in Subjects Admitted to Chest Pain Unit

Status unconfirmed

Conditions studied: Myocardial Infarction, Death, Cerebrovascular Accident, Congestive Heart Failure, Angina Pectoris

In brief

It is recognized that endothelial dysfunction is a major factor contributing to the atherogenic process. Abnormal function of the endothelium is detectable prior to obvious intimal lesions in patients with risk factors for atherosclerosis. Endothelial dysfunction is a systemic disorder and a key variable in the pathogenesis of atherosclerosis and its complications. Measurement of peripheral vasodilator response with fingertip peripheral arterial tonometry (PAT) technology (EndoPAT; Itamar Medical, Caesarea, Israel) is emerging as a useful method for assessing vascular function. EndoPAT may be a potential valid test increasing the accuracy, sensitivity and specificity for detection of subjects to chest pain unit (CPU) with chest pain but no obvious coronary artery disease (CAD). This is a relatively fast non-invasive bedside test, relatively low-cost and has no side effects. Therefore, the primary objective of the study is to test the hypothesis that abnormal endothelial function as assessed by EndoPAT testing will increase the prediction of the short (in-hospital) and long-term (1-year) outcome of patients presenting to the chest pain unit.

Key facts

Study ID

NCT01618123

Run by

Sheba Medical Center

People needed

300

Starts

2012-10-01

Expected to finish

2025-12-01

Last updated by the study team

2023-12-12

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All subjects admitted to the CPU with low to moderate probability for CAD and negative troponin.

You may not qualify if…

• Subjects with chest pain and positive troponin.

Where it is running

• Mayo Clinic Chest Pain Unit, Emergency Department — Rochester, Minnesota, United States
• Chest Pain Unit, Chaim Sheba Emergency Department — Tel Litwinsky, Israel

Full record on ClinicalTrials.gov

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