Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis

Withdrawn before enrolling · Not applicable · Has a placebo group

Conditions studied: Respiratory Failure, Volume Overload, Hypernatremia

In brief

Patients who are on mechanical ventilation in an intensive care unit often require diursis as part of their pre-extubation regimen. The drug of choice for diuresis has traditionally been furosemide. However, this drug cause hypernatremia (a rise in serum sodium) in a significant proportion of patients. Hypernatremia is traditionally treated by providing free water supplementation to the patient. This strategy creates a vicious and unproductive cycle of giving free water, and then diuresing it off. We propose a strategy for breaking this cycle by using a second diuretic-- metolazone-- which has a tendency to rid the body of more sodium, thereby minimizing hypernatremia.

Key facts

Study ID: NCT01617798
Run by: Oregon Health and Science University
People needed: 0
Starts: 2012-06-01
Expected to finish: 2013-06-01
Last updated by the study team: 2019-06-06

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

ICU patients who are intubated and slated for diuresis in anticipation of extubation.
Patients must be hypernatremic (Na > 140 mEq/L) at the time diuresis is initiated or become hypernatremic over the course of receiving loop diuretics in anticipation of extubation.
GFR > 30 ml/min [as calculated by the MedCalc MDRD formula {GFR = 170 x PCr - 0.999 x Age - 0.176 x BUN - 0.170 x Albumin0.318 x 0.762 (for women) x 1.180 (for blacks)} ]

You may not qualify if…

History of allergy to furosemide or any thiazide diuretic
Inability to place enteral access
Moribund status

Where it is running

Oregon Health Sciences University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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