A Composite MR Neuroimaging Marker for Alzheimer's Disease
Withdrawn before enrolling
Conditions studied: Alzheimer's Disease, Mild Cognitive Impairment, Frontotemporal Dementia
In brief
The purpose of this study is to use a functional MRI (fMRI) index to compare the brain activity of healthy volunteers to that of people with mild cognitive impairment (MCI) and Alzheimer's disease. The ultimate goal is to develop an early diagnostic tool for Alzheimer's disease. The study hypotheses are: 1. The fMRI index will differentiate between Alzheimer's disease, non-Alzheimer's dementia, and healthy volunteers; 2. The fMRI index will distinguish participants with MCI who convert to Alzheimer's disease from those who convert to a non-Alzheimer's dementia and those who remain stable; 3. MCI participants with a lower fMRI index at baseline who convert will progress to Alzheimer's sooner than those with a higher fMRI index, and MCI participants with a faster rate of fMRI index decline who convert will have an earlier onset of Alzheimer's disease.
Key facts
- Study ID
- NCT01615666
- Run by
- Medical College of Wisconsin
- People needed
- 0
- Starts
- 2009-03-01
- Expected to finish
- 2016-01-01
- Last updated by the study team
- 2016-01-14
Who can join
Age: 50 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 60 years of age or older (50 years of age or older for frontotemporal dementia patients)
- Normal memory, mild cognitive impairment (memory loss that does not significantly affect normal daily activities), or clinical diagnosis of Alzheimer's disease or frontotemporal dementia (includes primary progressive aphasia)
- Right-handed
- General good physical health
You may not qualify if…
- History of stroke or neurological disease (other than Alzheimer's disease or frontotemporal dementia)
- Seizures or head injury with loss of consciousness within the last five years
- Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
- Claustrophobia
Where it is running
- Medical College of Wisconsin/Froedtert Hospital — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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