Premarin Versus Toviaz for Treatment of Overactive Bladder
Status unconfirmed · Phase 4 · Has a placebo group
Conditions studied: Overactive Bladder
In brief
The use of vaginal estrogen cream in conjunction with Toviaz will be more effective than the use of Toviaz alone for the treatment of overactive bladder.
Key facts
- Study ID
- NCT01613170
- Run by
- The Cleveland Clinic
- People needed
- 90
- Starts
- 2012-04-01
- Expected to finish
- 2018-12-01
- Last updated by the study team
- 2017-04-20
Who can join
Age: 30 and older, up to 100. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Postmenopausal Women defined as at least 12 months since last menstrual period
- OAB symptoms for 6 months or longer with complaints of frequency (8 or more voids in a 24 hour period), and either 6 or more urgency episodes in 24 hours, and either 3 or more urge urinary incontinence episodes per 24 hours.
You may not qualify if…
- Current or recent treatment (within the last 6 months) with estrogens
- Past or present history of estrogen dependent neoplasm
- Undiagnosed genital tract bleeding
- Current urinary or vaginal infection
- History of thromboembolic disorders associated with estrogen use
- Commencement or alteration of diuretic therapy within three months of study enrollment
- No contraindications for anticholinergic medical therapy
- No contraindications to estrogen therapy
- Symptoms must not have commenced more than three years prior to menopause
- Post Void Residual must be under or equal to 150 ml
- Recurrent Urinary Tract Infections (3 culture proven UTI's within the past 12 months)
- Not on any other anticholinergic medications for the last 4 weeks
- Painful Bladder Syndrome
- Chronic Pelvic Pain
- Vaginal Prolapse POPQ > stage 2/ maximal prolapse point greater than +1 cm
Where it is running
- Cleveland Clinic Florida — Weston, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.