Acute Glycine Pharmacodynamic Study
Completed · Not applicable
Conditions studied: Schizophrenia, Psychotic Disorders
In brief
The purpose of this study is to use proton magnetic resonance spectroscopy (MRS) at 4 Tesla to measure brain glycine levels noninvasively at baseline and for 2 hours after a single oral dose of a concentrated glycine-containing beverage, and to compare MRS glycine measurements to glycine blood levels in samples obtained after each MRS spectrum. The investigators hypothesize that they will observe a high correlation between the magnitude increases in brain and plasma glycine levels over this time frame. The investigators also hypothesize that we will observe large intersubject variability in glycine uptake rates into brain and blood. The investigators also hypothesize that subjects with a glycine decarboxylase (GLDC) mutation (triplication) will have lower baseline plasma and brain glycine levels and will experience smaller brain and plasma glycine increases after glycine consumption than controls or family members without the GLDC mutation.
Key facts
- Study ID
- NCT01610011
- Run by
- Mclean Hospital
- People needed
- 21
- Starts
- 2010-07-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2015-10-27
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy Adult males
- Members of a family known to the research team with some members possessing a GLDC genetic mutation
You may not qualify if…
- Contraindications to magnetic resonance scanning including metallic surgical implants or claustrophobia
- History of head injury with loss of consciousness > 5 minutes
- Brain structural abnormalities identified on MRI scan
- Known sensitivity or allergy to glycine
- History of taking glycine or other dietary supplements
- Healthy controls: history of psychiatric or substance use disorders; individuals taking prescription medications
- Pregnancy
Where it is running
- McLean Imaging Center, McLean Hospital — Belmont, Massachusetts, United States
Full record on ClinicalTrials.gov
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