Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Chronic Sinusitis

In brief

The purpose of this study is to assess the use of IV acetaminophen (Ofirmev) as a and safe and efficacious agent in reducing post-operative pain; we hypothesize that its use will reduce post-operative pain when compared to a control group using the visual analogue score (VAS) analog pain scoring system.

Key facts

Study ID

NCT01608308

Run by

The University of Texas Health Science Center, Houston

People needed

62

Starts

2012-07-01

Expected to finish

2014-09-01

Last updated by the study team

2015-10-16

Who can join

Age: 18 and older, up to 68. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing surgical management for CRS (with or without polyps)
• Operating time must be at least 2 hours in duration.
• Number of sinuses involved must be 3 or greater

You may not qualify if…

• History of hypersensitivity to acetaminophen
• End stage renal disease
• End stage liver disease
• History of chronic pain, or use of opioid medication in the previous two weeks
• Severe depression or anxiety
• Use of gabapentin or any other pain modulator
• History of acute sinusitis or mucocele
• History of seizures
• Known or suspected history of alcohol or drug abuse
• Known or suspected history of morphine intolerance

Where it is running

• The University of Texas Health Sciences Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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