Locating Regions of Interest in Generalized Anxiety Disorder Using Function Magnetic Resonance Imaging (fMRI)
Completed
Conditions studied: Generalized Anxiety Disorder
In brief
The investigators are seeking to locate the brain regions of interest in generalized anxiety disorder (GAD) using both structural (sMRI) and functional magnetic resonance imaging (fMRI). The MRI will be used to measure changes in blood flow in the brain while at rest and while completing tasks designed to elicit symptoms of anxiety. Results from a nonclinical control group and a GAD group will be compared to determine whether they exhibit different areas of brain activity during the tasks.
Key facts
- Study ID
- NCT01607710
- Run by
- Hartford Hospital
- People needed
- 55
- Starts
- 2012-07-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2014-09-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Clinical diagnosis of Generalized Anxiety Disorder
- Hamilton Anxiety Rating Scale score of 18 or higher
- Hamilton Rating Scale for Depression score of 17 or less
- Fluency in English
- Capacity to understand the nature of the study and willingness to sign informed consent for
You may not qualify if…
- History of epilepsy or head trauma (Loss of consciousness>5 minutes) with the past 6 months
- Lifetime history of increased intracranial pressure, seizure disorder, stroke, brain tumor, multiple sclerosis or brain surgery
- A review of patient medications by the study physician indicates an increased risk of seizure
- An active autoimmune, endocrine, viral, or vascular disorder affecting the brain; any unstable cardiac disease; hypertension; or severe renal or liver insufficiency
- Substance use disorder or posttraumatic stress disorder (PTSD) within the past 6 months
- Lifetime bipolar disorder, obsessive-compulsive disorder (OCD), psychotic disorder, mental retardation, or pervasive development disorder
- Any psychotic features, including dementia or delirium
- Medication change within past 3 months
- Current serious suicidal or homicidal ideation, and/or serious suicidal attempt within past 6 months
- Serious, unstable, or terminal medical condition or clinically judged too psychiatrically unstable to participate in the study
- Any contraindication for participation in MRI scan
- Nonclinical Control Group:
- Inclusion Criteria:
- Absence of any psychiatric diagnosis
- Exclusion Criteria:
- History of epilepsy or head trauma (Loss of Consciousness>5 minutes) with the past 6 months
- Lifetime history of increased intracranial pressure, seizure disorder, stroke, brain tumor, multiple sclerosis or brain surgery
- A review of patient medications by the study physician indicates an increased risk of seizure
- An active autoimmune, endocrine, viral, or vascular disorder affecting the brain; any unstable cardiac disease; hypertension; or severe renal or liver insufficiency
- Substance use disorder or PTSD within the past 6 months
- Lifetime bipolar disorder, OCD, psychotic disorder, mental retardation, or pervasive development disorder
- Any psychotic features, including dementia or delirium
- Medication change within past 3 months
- Current serious suicidal or homicidal ideation, and/or serious suicidal attempt within past 6 months
- Serious, unstable, or terminal medical condition or clinically judged too psychiatrically unstable to participate in the study
Where it is running
- Hartford Hospital — Hartford, Connecticut, United States
Full record on ClinicalTrials.gov
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