Bridging Study of C11 Pittsburgh Compound B (PiB) and F18 Flutemetamol Brain Positron Emission Tomography (PET)
Completed · Phase 2
Conditions studied: Alzheimer's Disease
In brief
The intent of this research protocol is to test the equivalency of two amyloid imaging drugs (C11 Pittsburgh Compound B and F18 Flutemetamol). The investigators hypothesize that there will be no significant difference in the distribution of the agents to areas of amyloid deposition in the brain or to other normal brain structures. Recent data have shown similarity in the distribution of the drugs in subjects with Alzheimer's disease (AD) or mild cognitive impairment (MCI). No comparison data of the two PET drugs in normal subjects has been published. It is important to understand differences in the images and biodistribution from the two drugs in normal subjects as nonspecific accumulation of the drugs in brain structures such as white matter appear to differ slightly and could affect image performance.
Key facts
- Study ID
- NCT01607476
- Run by
- Mayo Clinic
- People needed
- 89
- Starts
- 2012-07-01
- Expected to finish
- 2016-03-01
- Last updated by the study team
- 2017-04-18
Who can join
Age: 30 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males or females 30 years of age or older.
- Subjects who have the clinical diagnosis of probable AD (30) ages 50 and older who have a study partner who is the participant's power of attorney (POA) or legally authorized representative (LAR), cognitive normal elderly (30) age >60 and cognitive normal young subjects (30) ages 30-60.
- Normal subjects with Clinical Dementia Rating (CDR) 0-0.5 and AD subjects with CDR of 0.5 or greater.
You may not qualify if…
- Subjects unable to lie down without moving for 30 minutes.
- Women who are pregnant or who cannot stop breast feeding for 24 hours.
- Standard safety exclusionary criteria for MRI such as metallic foreign bodies, pacemaker, etc,.
- Subjects who are too claustrophobic to perform the tests.
- Subject who have had previous brain irradiation, stroke or brain tumor(s)
Where it is running
- Mayo Clinic Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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