Comparative Efficacy of Water & Indigo Carmine vs. Water or Air Method on Adenoma Detection Rate (ADR) - a Randomized Controlled Trial (RCT)

Completed · Phase 4

Conditions studied: Colorectal Neoplasms

In brief

Adenoma detection rate (ADR) is a quality indicator of colonoscopy performed for colorectal cancer screening. Population studies have shown that traditional air colonoscopy fails to eliminate post screening colonoscopy cancers or cancer mortality in the proximal colon. The investigators aim to establish the superior effectiveness of combining chromoendoscopy with the water exchange method in detecting more proximal diminutive adenomas during screening colonoscopy in sedated Veterans. An improved adenoma detection rate associated with optical colonoscopy will minimize the risk of missed lesions. The improvement may translate into a remedy for the limitations of screening colonoscopy in the proximal colon, e.g. a higher adenoma detection rate may minimize the burden of post screening colonoscopy interval colorectal cancers among the veteran population.

Key facts

Study ID

NCT01607255

Run by

VA Office of Research and Development

People needed

480

Starts

2013-05-16

Expected to finish

2017-09-30

Last updated by the study team

2019-01-15

Who can join

Age: 45 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• asymptomatic Veterans scheduled for first time screening colonoscopy and agree to be randomized will be enrolled.

You may not qualify if…

• patients who decline to be randomized, non screening cases.

Where it is running

• VA Northern California Health Care System, Mather, CA — Sacramento, California, United States

Full record on ClinicalTrials.gov

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