Lumbar Punctures in Neonates: Improving Success Rates and Minimizing Pain
Stopped early · Not applicable
Conditions studied: Meningitis
In brief
The purpose of this study is to compare two medications used to numb an infant's back when performing a lumbar puncture. A lumbar puncture (LP) is often needed in newborns to obtain cerebrospinal fluid (CSF). This is achieved by inserting a small needle between the infant's vertebrae. In the past, doctors did not know if newborns could feel the pain from a procedure like this in the same way that adults do. Investigators now know that the newborns do experience pain during this procedure, but we do not know the best way to control this pain. Investigators also think that when the newborns have pain, they move during the test. The movement can increase the chance of having blood mix with this normally clear fluid leading to limitations in our clinical application of these results. This study will compare the injected and topical forms of Lidocaine to see which gives us better pain control and more clear results. The investigators hypothesize that subcutaneous 1% Lidocaine, due to its deeper penetration, will be 25% superior to topical liposomal Lidocaine (LMX-4) in both the rate of clinically useful results and pain scores. The investigators hypothesize that both forms of Lidocaine will be 25% superior to our historical control cohort in the rate of clinically useful results.
Key facts
- Study ID
- NCT01606150
- Run by
- Georgetown University
- People needed
- 5
- Starts
- 2012-11-01
- Expected to finish
- 2014-07-01
- Last updated by the study team
- 2016-12-13
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- neonate requiring lumbar puncture
- gestational age at birth equal to or greater than 34 weeks
You may not qualify if…
- on mechanical ventilation
- receiving sedation (opioids or benzodiazepines)
- suspected congenital spinal anomaly
- infants older than 1 week of life
Where it is running
- MedStar Georgetown University Hospital — Washington D.C., District of Columbia, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.