Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans

Completed · Phase 2

Conditions studied: Opiate Addiction

In brief

Despite the current available therapies for opioid-dependent patients, most patients relapse. This research project focuses on the development of a novel compound, cannabidiol, to modulate opioid craving in humans based on animal models showing its selective effectiveness to inhibit drug-seeking behavior. The development of a targeted treatment for opioid relapse would be of tremendous medical and public health value.

Key facts

Study ID: NCT01605539
Run by: Hurd,Yasmin, Ph.D.
People needed: 10
Starts: 2012-05-01
Expected to finish: 2013-10-01
Last updated by the study team: 2020-08-11

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Must be between 21 and 65 years old
Must have an opiate dependence that meets criteria set in the Structured Clinical Interview for DSM-IV(SCID-IV) over the last three months
No opioid use in the past 7 days (will be verified via urine drug screen and opiate metabolite test)

You may not qualify if…

Using any psychoactive drug (other than nicotine) any time up to test session 3
Having a diagnosis of drug dependence (except for heroin or nicotine) in the past 3 months, based on the SCID-IV interview criteria
Being maintained on methadone or buprenorphine, or taking opioid antagonists such as naltrexone
Having a positive a drug screen
Showing signs of acute heroin withdrawal symptoms
Having medical conditions, including Axis I psychiatric conditions under DSM-IV (examined using the Mini International Neuropsychiatric Interview [MINI])
Having a a history of cardiac disease, arrhythmias, head trauma, and seizures
Having a history of hypersensitivity to cannabinoids
Arriving to the study site visibly intoxicated as determined by a clinical evaluation for signs and symptoms of intoxication and as verified by a drug screen
Participating in a another pharmacotherapeutic trial in the past 3 months
Being pregnant of breastfeeding
Not using or irregularly using appropriate methods of contraception such as hormonal contraceptives (e.g., Depo-Provera, Nuva-Ring), an intrauterine device (IUD), or double barrier method (combination of any two barrier methods used simultaneously, e.g., condoms, spermicide, diaphragms)

Where it is running

Mount Sinai Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.