Can Nebivolol Reverse Inappropriate Left Ventricular Mass in Hypertensive Patients?
Stopped early · Phase 4
Conditions studied: Hypertension
In brief
The purpose of this study is to evaluate if a drug called nebivolol can reverse inappropriate left ventricular mass (LVM) when compared to the standard of care drug metoprolol.
Key facts
- Study ID
- NCT01605370
- Run by
- Mayo Clinic
- People needed
- 1
- Starts
- 2012-06-01
- Expected to finish
- 2013-03-01
- Last updated by the study team
- 2014-05-19
Who can join
Age: 30 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Presence of inappropriate LVM.
- Presence of phenotype of inappropriate LVM.
You may not qualify if…
- The criteria will assure that only patients with hypertension are enrolled, that is, excluded will be subjects with systolic BP < 140 or diastolic BP < 90 (ie, prehypertension or normal BP), but without complications or any indication (or suspicion) of end-organ damage based on a physical exam, clinical history, or laboratory tests.
- Specific exclusion criteria are:
- Reactive airways disease including asthma.
- Diabetes mellitus or hypoglycemia; thyrotoxicosis.
- LV dysfunction (ejection fraction < 50%) or heart failure.
- Present or previously documented coronary heart disease or angina.
- Acute myocardial infarction, or history of myocardial infarction.
- Severe bradycardia, heart block greater than first degree or sick sinus syndrome (unless a permanent pacemaker is in place).
- Hepatic insufficiency or history of cirrhosis.
- Chronic renal failure or renovascular dysfunction.
- Cerebrovascular dysfunction.
- Peripheral vascular disease.
- Pregnant or nursing women; women of childbearing age will be required to take a pregnancy test at the time of enrollment and use an acceptable method of birth control.
- Poor echo image quality.
Where it is running
- Mayo Clinic Arizona — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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