11C Acetate Imaging Post Prostatectomy

Stopped early · Not applicable

Conditions studied: Prostate Cancer

In brief

This research is being conducted to test an imaging technique that may be able to detect small amounts of prostate cancer that can not be detected by standard imaging. Many patients who are diagnosed with prostate cancer undergo surgery to remove the prostate. After this surgery, some patients have a PSA blood test that reveals a low but detectable level of PSA. This PSA may be produced by cancer cells in one of two locations: (1) near the area where the prostate used to be, or (2) elsewhere in the body. If the cancer is only in the area where the prostate used to be, it can be successfully treated with radiation to that area. If the cancer is elsewhere, radiation is not helpful. Currently, there is no available scan that can detect cancer when the PSA is still so low. The test used in this study is called \[11C\] acetate PET screening. \[11C\] acetate is a radioactive tracer that is given by vein to patients before PET scanning. The PET scanner then detects radioactivity from the tracer that is attached to cells within your body and uses this information to create images (pictures) on a computer screen. \[11C\] acetate PET scanning has been shown in early studies to detect smaller amounts of prostate cancer that can be detected by standard imaging tests such as CT scan and bone scan. If it is successful at detecting very small amounts of prostate cancer, \[11C\] acetate PET scanning will help doctors identify patients who will benefit from radiation therapy after their prostate has been surgically removed. It will also help them identify patients who have small amounts of prostate cancer in other parts of the body and will not benefit from radiation to the prostate area. This type of PET scan is investigational. "Investigational" means that the scan is still being studied and that research doctors are trying to find out more about it. It also means that the FDA has not approved this type of PET scan for your type of cancer. The information collected by this scan will determine whether this type of scanning is helpful but it will not be used to make decisions about your medical care.

Key facts

Study ID

NCT01602783

Run by

Massachusetts General Hospital

People needed

2

Starts

2011-12-01

Expected to finish

2014-02-01

Last updated by the study team

2014-03-18

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed adenocarcinoma of the prostate
• History of radical prostatectomy
• Age ≥18 years
• PSA ≥0.5 and <4.0 ng/mL
• Abdominal-Pelvic CT scan without evidence of prostate cancer
• 99mTc MDP bone scan without evidence of prostate cancer
• Patient and clinician decision to proceed to salvage pelvic radiation therapy

You may not qualify if…

• Presence of known extra-pelvic evidence of prostate cancer
• Unable to fast for 4 hours
• Uncontrolled diabetes
• History of bilateral orchiectomies
• Ongoing treatment with any systemic therapy intended for the treatment of prostate cancer

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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