Hsp90 Inhibitor AUY922 in Treating Older Patients With Advanced Solid Malignancies

Stopped early · Phase 1

Conditions studied: Unspecified Adult Solid Tumor, Protocol Specific

In brief

This phase I trial studies the side effects and best dose of Hsp90 inhibitor AUY922 in treating older patients with advanced solid malignancies. Hsp90 inhibitor AUY922 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth

Key facts

Study ID

NCT01602627

Run by

Dale Shepard, MD, PhD

People needed

2

Starts

2011-09-01

Expected to finish

2012-02-01

Last updated by the study team

2013-02-07

Who can join

Age: 75 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have a histologically proven solid tumor malignancy which is refractory to standard therapy and for which no curative therapy is available
• Patients must have at least one measurable lesion as defined by Response Evaluation Criteria in Solid Tumors (RECIST); irradiated lesions are only evaluable for disease progression
• Eastern Cooperative Oncology Group (ECOG) Performance Status of =< 1
• Life expectancy of >= 12 weeks
• Absolute neutrophil count (ANC) >= 1.5 x 10\^9/L
• Hemoglobin (Hgb) >= 9 g/dl
• Platelets (plt) >= 100 x 10\^9/L
• Potassium within normal limits or correctable with supplements
• Total calcium (corrected for serum albumin) and phosphorus within normal limits
• Magnesium above lower limit of normal (LLN) or correctable with supplements
• Aspartate aminotransferase (AST)/serum glutamic oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT)/serum glutamic pyruvic transaminase (SGPT) =< 2.5 x upper limit of normal (ULN) if no liver metastases are present
• AST/SGOT and ALT/SGPT =< 5 x ULN if liver metastases are present
• Serum bilirubin =< 1.5 x ULN
• Serum creatinine =< 1.5 x ULN or 24-hour clearance >= 50 ml/min
• Patients must be able to understand and voluntarily sign written informed consent
• Male participants with partners who are of child bearing potential must:
• Agree to use double barrier method of birth control 28 days prior to study entry, during course of study and for 28 days following the last dose of AUY922
• OR have history of a vasectomy

You may not qualify if…

• Patients with central nervous system (CNS) metastasis which are:
• Symptomatic or
• Require treatment for symptom control and/or
• Growing Note: Patients without clinical signs or symptoms of CNS involvement are not required to have a computed tomography (CT)/magnetic resonance imaging (MRI) of the brain
• Prior treatment with any heat shock protein (HSP)90 or histone deacetylase (HDAC) inhibitor compounds
• Patients who received systemic anti-cancer treatment prior to the first dose of AUY922 within the following time frames:
• Radiotherapy or conventional chemotherapy: within 4 weeks
• Palliative radiotherapy: within 2 weeks
• Nitrosoureas, mitomycin, or monoclonal antibodies, such as trastuzumab, within 6 weeks
• Any systemic anti-cancer treatment for which the elimination period is not known, or investigational drugs (i.e. targeted agents) within a duration of =< 5 half lives of the agent and their active metabolites (if any)
• Treatment with therapeutic doses of coumadin-type anticoagulants (maximum daily dose of 2 mg, for line patency permitted)
• Unresolved diarrhea >= Common Terminology Criteria for Adverse Events (CTCAE) grade 1, despite treatment with antidiarrheal agents
• Patients with malignant ascites that require invasive treatment
• Male patients whose partners are women of child-bearing potential (WCBP) not using double-barrier methods of contraception
• Acute or chronic liver or renal disease
• Other concurrent severe and/or uncontrolled medical conditions that could cause unacceptable safety risks or compromise compliance with the protocol
• Major surgery =< 2 weeks prior to Cycle 1, Day 1 or who have not recovered from such therapy; (placement of a venous access device within 2 weeks is permitted)
• Impaired cardiac function, including any one of the following:
• History (or family history) of long QT syndrome
• Mean corrected QT interval (QTc) >= 450 msec on baseline electrocardiogram (ECG)
• History of clinically manifested ischemic heart disease =< 6 months prior to study start
• History of heart failure or left ventricular (LV) dysfunction (left ventricular ejection fraction [LVEF] =< 45%) by multigated acquisition scan (MUGA) or echocardiogram (ECHO)
• Clinically significant ECG abnormalities including 1 or more of the following: left bundle branch block (LBBB), right bundle branch block (RBBB) with left anterior hemiblock (LAHB); ST segment elevation or depression > 1mm, or 2nd (Mobitz II), or 3rd degree atrioventricular (AV) block
• History or presence of atrial fibrillation, atrial flutter or ventricular arrhythmias including ventricular tachycardia or Torsades de Pointes
• Other clinically significant heart disease (e.g. congestive heart failure, uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen)

Where it is running

• Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.