Study of Exelon Transdermal Patch in Amnestic Mild Cognitive Impairment Patients

Stopped early · Not applicable · Has a placebo group

Conditions studied: Mild Cognitive Disorder, Mild Cognitive Impairment

In brief

The goal of this project is to determine if task-activated fMRI is sensitive to the central cholinergic deficit associated with Mild Cognitive Impairment.

Key facts

Study ID

NCT01602198

Run by

The Cleveland Clinic

People needed

1

Starts

2011-06-01

Expected to finish

2013-01-01

Last updated by the study team

2017-02-28

Who can join

Age: 55 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of amnestic MCI
• In good general health with no diseases expected to interfere with the study
• Ability to undergo MRI
• Fluent in English
• Stable prescription dosages 1 month prior to testing
• Carrier of the APOE e4 allele (determined by blood draw at screening visit)

You may not qualify if…

• Neurological illness/conditions
• Medical illnesses/conditions that may affect brain function
• Prior history of use of any cholinesterase inhibitor
• Instable or severe cardiovascular disease or asthmatic condition

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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