Study of MLN8237 in Combination With Irinotecan and Temozolomide
Completed · Phase 1/Phase 2
Conditions studied: Neuroblastoma
In brief
The goal of the first part of this clinical trial (Phase I portion) is to study the side effects, drug breakdown (pharmacokinetics), and dosing of the drug MLN8237 when added to standard chemotherapy drugs, irinotecan and temozolomide. The goal of the second part of this clinical trial (Phase II portion) is to learn how many children and young adults show improvements in their neuroblastoma when treated with the combination of MLN8237, irinotecan, and temozolomide.
Key facts
- Study ID
- NCT01601535
- Run by
- New Approaches to Neuroblastoma Therapy Consortium
- People needed
- 54
- Starts
- 2012-05-01
- Expected to finish
- 2018-07-25
- Last updated by the study team
- 2019-07-31
Who can join
Age: 1 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Hospital Los Angeles — Los Angeles, California, United States
- Lucile Packard Children's Hospital at Stanford University Medical Center — Palo Alto, California, United States
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- Children Hospital of Colorado — Aurora, Colorado, United States
- Children's Healthcare of Atlanta — Atlanta, Georgia, United States
- University of Chicago Comer Children's Hospital — Chicago, Illinois, United States
- Childrens Hospital Boston, Dana-Farber Cancer Institute. — Boston, Massachusetts, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Cook Children's Medical Center - Fort Worth — Fort Worth, Texas, United States
- Children's Hospital and Regional Medical Center - Seattle — Seattle, Washington, United States
- Hospital for Sick Children — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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