Resistance Exercise in Rheumatic Disease
Stopped early · Not applicable
Conditions studied: Rheumatoid Arthritis, Systemic Vasculitis
In brief
People with rheumatic disease often have decreased strength, muscle mass, and bone mineral density due to repeated bouts of inflammation, normal effects of aging, disuse, and inactivity. The medications used to quell the disease process, such as prednisone, can also have detrimental effects on body composition, strength, and functional capacity. The investigators propose to investigate the feasibility, safety, and effects of resistance exercise in older patients with rheumatoid arthritis (RA) and vasculitis. The unique resistance protocol the investigators propose involves performing movements in a slow and controlled fashion (i.e., no acceleration or use of momentum in the lifting and lowering of the resistance) to minimize force on the joints and connective tissues. This will be conducted in an individually-supervised environment with a new generation of exercise equipment that will accommodate their musculoskeletal capabilities and allow for reproducibility of the exercise protocol. The investigators intend to investigate the feasibility, safety, musculoskeletal, and psychological effects of this resistance exercise protocol in older patients with rheumatoid arthritis and vasculitis by testing their strength, body composition, functional ability, mood, and quality of life before and after this 16-week resistance exercise intervention.
Key facts
- Study ID
- NCT01599260
- Run by
- Johns Hopkins University
- People needed
- 15
- Starts
- 2012-05-01
- Expected to finish
- 2018-12-01
- Last updated by the study team
- 2019-04-09
Who can join
Age: 45 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- diagnosis of rheumatoid arthritis OR systemic vasculitis (defined as granulomatosis with polyangiitis, Churg-Strauss, microscopic polyangiitis, Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, or giant cell arteritis)
You may not qualify if…
- Non-English speaking
- Pregnancy
- Absolute cardiac or pulmonary contraindication to exercise
- pacemaker
Where it is running
- Johns Hopkins Bayview Medical Campus — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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