Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain Function
Completed · Not applicable
Conditions studied: Major Depressive Disorder
In brief
The purpose of this study is to understand the effectiveness of a ten-week internet-based cognitive behavioral therapy (iCBT) treatment on improving depressive symptoms, coping and resilience skills, and cognitive processing.
Key facts
- Study ID
- NCT01598922
- Run by
- Mclean Hospital
- People needed
- 77
- Starts
- 2012-10-01
- Expected to finish
- 2015-08-01
- Last updated by the study team
- 2021-05-25
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age range between 18 and 45.
- Subjects must be right handed (as measured by Edinburgh Handedness Inventory).
- The primary language of the subjects must be English
- Must have regular access to a computer with internet connection and printer (for potential MDD or MAC participants)
- DSM-IV criteria for current Major Depressive Episode according to SCID (for enrollment into MDD or MAC groups)
- Absence of any psychotropic medications for at least 2 weeks (6 weeks for fluoxetine; 6 months for neuroleptics; 2 weeks for benzodiazepines; 2 weeks for any other antidepressants)
- PHQ-9 score below 5 (for enrollment into HC group)
You may not qualify if…
- Any history of neurological illness or brain injury
- Current or past DSM-IV Axis I disorder (for enrollment into HC group)
- Complicating medical conditions that may influence the outcome of neuropsychological assessment or functional imaging (e.g., HIV)
- Mixed or left-handedness
- Abnormal visual acuity that is not corrected by contact lenses
- Metal within the body, claustrophobia, or other contraindications for MRI
- Less than 9th grade education
- Past or current alcohol/substance dependence, or current alcohol abuse, or current or past substance abuse (i.e. past alcohol abuse is not exclusionary)
- Use of illicit drugs within the past year
- Use of marijuana within the past month
- Current use of opioid or prescribed stimulant medications
- History of a psychotic mental illness (schizophrenia or bipolar disorder)
- Current severe symptoms of depression (total score > 23 or responding > 1 to Question 9 for suicidal ideation in the Patient Health Questionnaire-9 Item [PHQ-9] (Kroenke et al., 2001))
- A PHQ-9 score below 10 (for potential MDD or MAC participants)
- Currently participating in Cognitive Behavior Therapy
- History of ECT treatment
Where it is running
- Isabelle Rosso — Belmont, Massachusetts, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.