An Observational Pilot Study Evaluating the Feasibility of Conducting Genome-Wide Association Studies Utilizing Subject Provided Information in Subjects With Locally Recurrent or MBC, MCRC, MNSCLC, RGBM or MRCC Treated With Avastin (Bevacizumab) (InVite)

Completed

Conditions studied: Breast Cancer, Colorectal Cancer, Non-Small Cell Lung Cancer, Glioblastoma, Renal Cell Cancer

In brief

This pilot, non-interventional, observational, Web-based, prospective cohort study is designed to collect self-reported safety and effectiveness and genetic data from subjects with locally recurrent breast cancer (BC) or metastatic breast cancer (MBC), metastatic colorectal cancer (MCRC), metastatic non-squamous non-small cell lung cancer (MNSCLC), recurrent glioblastoma (RGBM), or metastatic renal cell cancer (MRCC) in the United States who have been previously treated with Avastin (bevacizumab). The cohort will be composed of male and female subjects who have been diagnosed with locally recurrent BC or MBC, MCRC, MNSCLC, RGBM, or MRCC who have received treatment with bevacizumab in combination with chemotherapy, which started prior to or up to 31 December 2012. Participants will be self-referred to this study. They will be recruited online via a number of sources, including through the involvement of patient advocacy groups, social media tools, traditional media, physicians, and events to raise awareness of this study. After appropriate informed consent and authorization are obtained, data will be collected directly from subjects in an online survey. Participants will be contacted electronically to complete quarterly follow-up surveys. The follow-up period will be 1 year from responding to the baseline survey. DNA collection will be performed as part of this study. DNA will be extracted from saliva, which will be provided by the subject utilizing a collection kit sent to the participants for at-home use.

Key facts

Study ID

NCT01598597

Run by

Genentech, Inc.

People needed

276

Starts

2012-03-01

Expected to finish

2014-11-01

Last updated by the study team

2015-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Locally recurrent BC or MBC, MCRC, MNSCLC, RGBM, or MRCC in patients treated or on treatment with bevacizumab, which started prior to or up to 31 December 2012
• Ability to read and understand English
• Ability to access and use a computer connected to the Internet
• Signed informed consent and authorization form
• Residence in the United States
• At least 18 years of age

You may not qualify if…

• N/A

Where it is running

• Study site — Many Locations, Alabama, United States
• Study site — Many Locations, Alaska, United States
• Study site — Many Locations, Arizona, United States
• Study site — Many Locations, Arkansas, United States
• Study site — Many Locations, California, United States
• Study site — Many Locations, Colorado, United States
• Study site — Many Locations, Connecticut, United States
• Study site — Many Locations, Delaware, United States
• Study site — Many Locations, Florida, United States
• Study site — Many Locations, Georgia, United States
• Study site — Many Locations, Hawaii, United States
• Study site — Many Locations, Idaho, United States
• Study site — Many Locations, Illinois, United States
• Study site — Many Locations, Indiana, United States
• Study site — Many Locations, Iowa, United States
• Study site — Many Locations, Kansas, United States
• Study site — Many Locations, Kentucky, United States
• Study site — Many Locations, Louisiana, United States
• Study site — Many Locations, Maine, United States
• Study site — Many Locations, Maryland, United States
• Study site — Many Locations, Massachusetts, United States
• Study site — Many Locations, Michigan, United States
• Study site — Many Locations, Minnesota, United States
• Study site — Many Locations, Mississippi, United States
• Study site — Many Locations, Missouri, United States

Full record on ClinicalTrials.gov

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