Assessing Response to Treatment in Non-Hodgkin's Lymphoma Patients Using 64Cu-DOTA-Rituximab PET/CT

Withdrawn before enrolling · Not applicable

Conditions studied: Non-Hodgkin's Lymphoma

In brief

Rituximab is an antibody targeted against the CD20 antigen found primarily on B-cells. Therefore, an imaging agent targeting CD20 expression may provide a more accurate evaluation of extent of disease and response to therapy than the current standard of care, F-18 FDG PET/CT. The main purpose of the study is to investigate a new PET/CT imaging probe for detection and follow up of lymphoma. Following are the 3 aims of the study: a) Phase I testing in lymphoma patients of Cu-64 labelled Rituxan for defining normal tracer biodistribution, stability, pharmacokinetics and radiation dosimetry; b) comparison of Cu-64 Rituxan and F-18 FDG PET/CT in lymphoma patients; c) evaluation of changes in uptake of Cu-64 Rituxan in response to rituximab-based treatment in CD20-positive B-cell NHL

Key facts

Study ID

NCT01598558

Run by

Sanjiv Sam Gambhir

People needed

0

Starts

2012-01-01

Expected to finish

2015-12-01

Last updated by the study team

2016-10-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have a diagnosis of CD20-positive B-cell NHL and a staging 18F FDG PET/CT prior to the 64Cu-DOTA-Rituximab PET/CT
• Patients must understand and voluntarily sign an Informed Consent form after the contents have been fully explained to them
• Patients must be scheduled for rituximab-based therapy
• Patients must be older than 18-year-old

You may not qualify if…

• Patients who cannot complete a PET/CT scan
• Pregnant women
• Patients participating in other research protocols will be excluded from this study

Where it is running

• Stanford University Cancer Institute — Stanford, California, United States

Full record on ClinicalTrials.gov

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